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Stem Cell Res ; 51: 102168, 2021 03.
Article in English | MEDLINE | ID: covidwho-1019479

ABSTRACT

COVID-19 caused by a novel coronavirus named SARS-CoV-2, can elites severe acute respiratory syndrome, severe lung injury, cardiac injury, and even death and became a worldwide pandemic. SARS-CoV-2 infection may result in cardiac injury via several mechanisms, including the expression of angiotensin-converting enzyme 2 (ACE2) receptor and leading to a cytokine storm, can elicit an exaggerated host immune response. This response contributes to multi-organ dysfunction. As an emerging infectious disease, there are limited data on the effects of this infection on patients with underlying cardiovascular comorbidities. In this review, we summarize the early-stage clinical experiences with COVID-19, with particular focus on patients with cardiovascular diseases and cardiopulmonary injuries, and explores potential available evidence regarding the association between COVID-19, and cardiovascular complications.


Subject(s)
COVID-19/pathology , Cardiovascular Diseases/complications , Heart Diseases/complications , Animals , COVID-19/complications , COVID-19/transmission , COVID-19/virology , Cytokine Release Syndrome/etiology , Heart Diseases/prevention & control , Heart Failure/complications , Heart Failure/prevention & control , Humans , Myocarditis/complications , Myocarditis/prevention & control , SARS-CoV-2/isolation & purification
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